Enhancing CAR-T therapy using distinctions between CAR and TCR signaling

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12 Oct
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About the Session

  1. CD28-CARs do not need LCK for signaling whereas TCRs require LCK
  2. Disruption of LCK expression allows improved CAR-T efficacy against liquid and solid tumors
  3. Disruption of LCK expression allows allogeneic use – “off the shelf” CAR-T with no graft versus host potential
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