Cell
Enhancing CAR-T therapy using distinctions between CAR and TCR signaling
About the Session
- CD28-CARs do not need LCK for signaling whereas TCRs require LCK
- Disruption of LCK expression allows improved CAR-T efficacy against liquid and solid tumors
- Disruption of LCK expression allows allogeneic use – “off the shelf” CAR-T with no graft versus host potential
