Development of AAV-CRISPR-Cas13 as novel antiviral strategies against medically important viral diseases

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13 Oct
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About the Session

1.RNA viruses account for many human diseases and pandemic events but are often not targetable by traditional therapeutics modalities.

  1. This study demonstrates the use of a new bioinformatics pipeline, establishes AAV-CRISPR-Cas13-gRNAs design principles that confer effective antiviral function, demonstrates in vivo prophylactic and therapeutic outcomes in lethal enterovirus-infected mouse models.
  2. This study bolsters the feasibility of using AAVs as an efficient delivery vector for in vivo CRISPR-Cas13 antiviral treatment.
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