oHSV MVR-T7 series was genetically engineered to drive ectopic expression of the extracellular domain of CD19/BCMA.
Co-culture studies were performed to test the cell-killing activity of CD19/BCMA CAR-T combined with T7.
Antitumor activities of T7011 administrated via intratumoral (IT) or intraperitoneal (IP) in combination with CD19 CAR-T cells were assessed in immunodeficient and immunocompetent mice.