Defective viral genomes as RNA-based antiviral therapies

1.Are parasitic genomes that, when in the presence of wild type viruses, hijack key viral machinery in direct competition with wildtype virus.

2.They exist for all RNA viruses.

3.They can inhibit virus replication in cell culture through a variety of mechanisms.

4.They can be used as antiviral therapies in animal models.

5.They can mitigate virus infection and transmission by mosquitoes.

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